Grape Seed Extract Review & In-Depth Look


A common misconception is that Grape Seed Extract and Resveratrol (which is found in grapes) are the same thing.

Protect Your Heart

But they are actually two different molecules that both happen to be found in grapes. Resveratrol is a compound that has been shown to protect your heart and increase blood flow.

Increase Blood Flow

Grape Seed Extract may also increase blood flow [1], but it also has many other functions that separate it from Resveratrol.

What are the Benefits?

Lower Blood Pressure

One of the most popular benefits of grape seed extract is the ability it has to lower blood pressure. A 2009 study by Sivaprakasapillai et al found that taking 300mg of Grape Seed Extract per day for 4 weeks reduced both systolic and diastolic blood pressure in people with metabolic syndrome [2].

Studies have also shown a slight decrease in heart rate in people with metabolic syndrome.

Lower Total Cholesterol

Another benefit of Grape Seed Extract is that it may lower total cholesterol in people who are obese or suffering from metabolic syndrome. A study by Kar et al (2009) found that taking 600mg per day over 4 weeks decreased total cholesterol in Type II Diabetes sufferers [3].

Lowered Voluntary Food Intake

Another benefit that only has one study to back it up (so far) is that Grape Seed Extract may lead to lowered voluntary food intake (eating less).

The study did not look at appetite, but found that there was an average of 4% drop in food intake in 51 subjects [4].

This means that Grape Seed Extract could potentially work as a weight loss product, or appetite suppressant supplement by lowering the amount of food you eat each day.


Grape Seed Extract may also work as an aromatase-inhibitor, blocking the enzyme Aromatase which converts Testosterone into Estrogen, which is something that you would look for in a top anti-estrogen product. The evidence for this is limited at the moment, but many experts claim that Grape Seed Extract may help to boost Testosterone.

Side Effects?

There doesn’t appear to be any side effects whatsoever to taking Grape Seed Extract.

That doesn’t mean that you should ignore the dosage instructions, but it does appear to be completely harmless.


What dosage should you take?

In the studies that we’ve looked at, Grape Seed Extract seems to be effective at around 300mg (in fact the 2009 study by Sivaprakasapillai et al found it effective at 150mg).

The study by Kar et al found benefits (and no adverse effects) at 600mg.

  • Anywhere between 150mg and 600mg seems to be beneficial.

Final Thoughts

Grape Seed Extract looks like an effective supplement, that could definitely be of use to sufferers of metabolic syndrome, or people who are at risk of heart problems in the future. The effect it has on cholesterol and blood pressure would make it a great supplement for anyone who is on the path to Type II Diabetes or Obesity.

The potential for Grape Seed Extract to work as an appetite controller could see it being used in a lot of premium fat loss supplements, and its possible inhibition of Aromatase may make it a popular testosterone booster ingredient. A decent, all-round supplement ingredient.


[1] Clifton, PM. 2004. Effect of grape seed extract and quercertin on cardiovascular and endothelial parameters in high-risk subjects. Journal of Biomedicine & Biotechnology 2004(5): 272-278

[2] Sivaprakasapillai, B., Edirisinghe, I., Randolph, J., Steinberg, F., Kappagoda, T. 2009. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism: Clinical & Experimental 58(12): 1743-6

[3] Kar, P., Laight, D., Rooprai, H., Shaw, K., Cummings, M. 2009. Effects of grape seed extract in type II diabetes subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabetes Medicine 26(5): 526-31

[4] Vogels, N., Nijs, I., Westerterp-Plantenga, M. 2004. The effect of grape-seed extract on 24h energy intake in humans. European Journal of Clinical Nutrition 58(4): 667-73

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